Karl Rove has an editorial up at the Wall Street Journal regarding the Sotomayor pick. Although he admits that she'll probably be confirmed, Rove says that Republicans can "win the argument by making a clear case against the judicial activism she represents." I find that highly unlikely. Everyone already knows that Republicans are against "judicial activism." It's far more likely that the weak Republican leadership we have in Congress will just manage to look bad if they attack Sotomayor. I'm not sure why Rove thinks the current GOP has the skill and ability to turn a defeat into some sort of victory. This appears to be a no win situation for the Republican party.
No doubt political operatives are busy poring over every word she wrote, and searching for dirt that could derail the nomination. But in my opinion the whole thing is pointless from a Republican perspective. Why start a fight you can't win? President Obama is a liberal Democrat with a Democratic majority in Congress. He's going to nominate liberals to the court. That's a consequence of the election. There is very little the GOP can do about it, especially since he picked an obviously qualified candidate. Even if something comes up that disqualifies Sotomayor, we are just going to get another liberal nominee, possibly someone even worse.
Right now the GOP should be working relentlessly to build alliances with moderate and conservative Democrats to generate effective opposition to the president's domestic agenda. Picking a losing fight against a Supreme Court nominee -- who is replacing a liberal member of the court anyway -- is useless and possibly counterproductive.